Use Caution/Monitor.Serious - Use Alternative (1)doxepin, dexmethylphenidate. Monitor Closely (2)fedratinib will increase the level or effect of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. Generic Name Doxepin DrugBank Accession Number DB01142 Background. Effect of interaction is not clear, use caution. Use Caution/Monitor. Avoid or Use Alternate Drug.fluoxetine and doxepin both increase serotonin levels. . doxepin and histrelin both increase QTc interval. Antidepressant drugs. Monitor Closely (1)rivastigmine increases and doxepin decreases cholinergic effects/transmission. Avoid or Use Alternate Drug. doxepin increases and fenfluramine decreases sedation. doxepin and mirtazapine both increase sedation. Use Caution/Monitor. Serious - Use Alternative (1)doxepin and erythromycin ethylsuccinate both increase QTc interval. Effect of interaction is not clear, use caution. Use Caution/Monitor. Serious - Use Alternative (1)doxepin and lopinavir both increase QTc interval. Discontinue buprenorphine if serotonin syndrome is suspected.Serious - Use Alternative (1)buprenorphine, long-acting injection and doxepin both increase QTc interval. Effect of interaction is not clear, use caution. Use Caution/Monitor. Avoid or Use Alternate Drug. doxepin and panobinostat both increase QTc interval. Food Interactions Sometimes the foods we eat and the beverages we drink can also interact with our medications. Effect of interaction is not clear, use caution. Use Caution/Monitor. Sign up for free, and stay up to date on research advancements, health tips and current health topics, like COVID-19, plus expertise on managing health. Modify Therapy/Monitor Closely. Effect of interaction is not clear, use caution. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. doxepin increases and phendimetrazine decreases sedation. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Contraindicated. Minor (1)doxepin increases effects of miglitol by pharmacodynamic synergism. This site needs JavaScript to work properly. Modify Therapy/Monitor Closely. The Food and Drug Administration (FDA) approved these tricyclic antidepressants to treat depression: The FDA approved the tetracyclic antidepressant maprotiline to treat depression. Use Caution/Monitor. You'll soon start receiving the latest Mayo Clinic health information you requested in your inbox. Monitor Closely (1)sumatriptan intranasal and doxepin both increase serotonin levels. Serious - Use Alternative (1)doxepin and St John's Wort both increase serotonin levels. Use Caution/Monitor. Monitor Closely (2)glycopyrrolate inhaled and doxepin both decrease cholinergic effects/transmission. midazolam intranasal, doxepin. Modify Therapy/Monitor Closely. It is in the tricyclic antidepressant class of medications. Which Insomnia Drugs Are More Effective and Have Fewer Side Effects? Use Caution/Monitor. Use Caution/Monitor. Contact the applicable plan Use of anticholinergic drugs after administration of botulinum toxin-containing products may potentiate systemic anticholinergic effects. doxepin and dasatinib both increase QTc interval. Avoid coadministration with drugs known to prolong QT interval; if a drug known to prolong QT interval must be used, more frequent ECG monitoring is recommended. Avoid or Use Alternate Drug. doxepin and lofepramine both increase sedation. Use Caution/Monitor. Serious - Use Alternative (1)doxepin and dronedarone both increase QTc interval. Fexinidazole inhibits CYP3A4. Effect of interaction is not clear, use caution. doxepin and quinine both increase QTc interval. Minor/Significance Unknown. Use Caution/Monitor. OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Modify Therapy/Monitor Closely. Comment: Inhibition of uptake by adrenergic neurons. Monitor Closely (2)cenobamate, doxepin. diphenhydramine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Comment: Potential for increased risk of hypotension with concurrent use. Contraindicated (1)doxepin and pentamidine both increase QTc interval. meperidine and doxepin both increase sedation. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Avoid or Use Alternate Drug. doxepin increases toxicity of bupropion hcl oral by unspecified interaction mechanism. Disclaimer. Based on the mechanism of action of iobenguane, drugs that reduce catecholamine uptake or that deplete catecholamine stores may interfere with iobenguane uptake into cells, and thus, reduce iobenguane efficacy. These medications are believed to work by raising the amount of serotonin a hormone that helps regulate mood in the brain. Use Caution/Monitor. physostigmine increases and doxepin decreases cholinergic effects/transmission. Use Caution/Monitor. Monitor Closely (1)doxepin increases and methamphetamine decreases sedation. Use Caution/Monitor.Minor (1)butabarbital, doxepin. sevoflurane and doxepin both increase sedation. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)baclofen and doxepin both increase sedation. Avoid or Use Alternate Drug. Minor/Significance Unknown. Alzheimer's disease: Can exercise prevent memory loss? rivastigmine increases and doxepin decreases cholinergic effects/transmission. Use Caution/Monitor.doxepin and asenapine both increase QTc interval. Mechanism: unspecified interaction mechanism. Use Caution/Monitor. Monitor Closely (1)doxepin and selpercatinib both increase QTc interval. Use Caution/Monitor. Monitor Closely (1)valerian and doxepin both increase sedation. Other (see comment). doxepin and macimorelin both increase QTc interval. Use Caution/Monitor. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Use Caution/Monitor. Use Caution/Monitor. midazolam and doxepin both increase sedation. Minor/Significance Unknown. Use Caution/Monitor. Use Caution/Monitor.doxepin and nortriptyline both increase sedation. Avoid or Use Alternate Drug. Monitor Closely (1)dabrafenib will decrease the level or effect of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. J Clin Psychiatry. Monitor Closely (1)buprenorphine buccal and doxepin both increase sedation. doxepin increases and midodrine decreases sedation. Avoid or Use Alternate Drug. Initiate at low dose (25 mg/day); gradually titrate upward every 5-7 days, Dosage range: 25-300 mg/day PO, up to 150 mg/day as single dose, 3-6 mg PO within 30 minutes before bedtime; not to exceed 6 mg/day, Hepatic impairment/debilitated patients: 3 mg PO within 30 minutes before bedtime, Hepatic impairment: Use lower dose and adjust gradually for depression; initiate Silenor at 3 mg daily for insomnia, Starting dose: 3 mg PO within 30 minutes before bedtime, May increase to 6 mg PO HS if clinically indicated, Lower initial dose (ie, 10 mg/day) and adjust gradually; 10-25 mg PO qHS, May increase by 10-25 mg increments q3Day for inpatients and weekly for outpatients if tolerated, Avoid; strong anticholinergic and sedative effects; may cause orthostatic hypotension (Beers criteria), Consider alternatives; if must use, initiate with lower initial dose, May cause confusion and oversedation in elderly. Minor/Significance Unknown. Use Caution/Monitor.doxepin and tramadol both increase serotonin levels. doxepin and dihydroergotamine intranasal both increase serotonin levels. fosamprenavir increases levels of doxepin by decreasing metabolism. Estrogens and progestins may decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse effects. The information provided here is for informational purposes only. Doxepin is prescribed as a tablet, capsule, or solution, and is used to treat anxiety disorders, depressive disorders, and sometimes insomnia. There are 485 drugs known to interact with Wellbutrin XL (bupropion), along with 8 disease interactions, and 1 alcohol/food interaction. doxepin, safinamide. eliglustat increases levels of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Do not double the dose to catch up. Monitor Closely (1)doxepin increases and benzphetamine decreases sedation. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. AUC and Cmax increased by 66% and 69% respectively. liotrix increases effects of doxepin by Other (see comment). Accessed Aug. 13, 2019. Monitor Closely (1)trihexyphenidyl and doxepin both decrease cholinergic effects/transmission. Either increases toxicity of the other by serotonin levels. Contraindicated. desflurane and doxepin both increase QTc interval. doxepin decreases effects of brimonidine by pharmacodynamic antagonism. Use Caution/Monitor. Do not take it within 3 hours of a meal because the effect of the medication will be delayed.Do not take this medication unless you are able to get a full night of sleep (7-8 hours) before you must be active again.Dosage is based on your medical condition, age, and response to therapy. Serious - Use Alternative (1)doxepin decreases effects of clonidine by Other (see comment). Use Caution/Monitor. Use Caution/Monitor. Interaction with other medicines. Use Caution/Monitor.doxepin and sevoflurane both increase QTc interval. Use Caution/Monitor. Avoid or Use Alternate Drug. Comment: Risk of neurotoxicity in geriatric pts. Monitor Closely (1)flurazepam and doxepin both increase sedation. Comment: Barbiturates may increase adverse effects, including respiratory depression, produced by toxic doses of TCAs. butorphanol and doxepin both increase sedation. Sept. 11, 2019. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Discontinue buprenorphine if serotonin syndrome is suspected. Use Caution/Monitor. Oxidative metabolism of TCAs may be decreased by ethinyl estradiol. If unavoidable, decrease the CYP2D6 substrate dosage in accordance with approved product labeling. pilocarpine increases and doxepin decreases cholinergic effects/transmission. Monitor Closely (1)ipratropium and doxepin both decrease cholinergic effects/transmission. What is pancreatic cancer? For 2 weeks after abametapir application, avoid taking drugs that are CYP3A4 substrates. Monitor Closely (1)triclofos and doxepin both increase sedation. Modify Therapy/Monitor Closely. Avoid or Use Alternate Drug. All rights reserved. doxepin and entrectinib both increase QTc interval. Use Caution/Monitor. Hidradenitis suppurativa and biologics: Get the facts. doxepin and lofexidine both increase sedation. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation and dose adjustment. Use Caution/Monitor. informational and educational purposes only. doxepin and levoketoconazole both increase QTc interval. Minor (1)conjugated estrogens, doxepin. Avoid combinations; the risk of the interaction outweighs the benefit. Additive anticholinergic effects. Use Caution/Monitor. Modify Therapy/Monitor Closely. National Institute of Mental Health. Modify Therapy/Monitor Closely. Monitor Closely (1)echothiophate iodide increases and doxepin decreases cholinergic effects/transmission. With therapeutic doses of TCAs, barbiturates increase metabolism and decrease blood concentrations of TCAs. Use Caution/Monitor. doxepin, serdexmethylphenidate/dexmethylphenidate. Use Caution/Monitor. Avoid or Use Alternate Drug. Either increases levels of the other by decreasing metabolism. Contraindicated. A different medication may be necessary in those cases.Usually, insomnia is temporary and requires sleep medications only for a short time. Concomitant use of barbiturates, alcohol, or other CNS depressants may increase risk of hypoventilation, airway obstruction, desaturation, or apnea and may contribute to profound and/or prolonged drug effect. Use Caution/Monitor. doxepin, phentermine. Minor/Significance Unknown. Comment: Barbiturates may increase adverse effects, including respiratory depression, produced by toxic doses of TCAs. doxepin increases and methamphetamine decreases sedation. Use Caution/Monitor.diphenhydramine and doxepin both increase sedation. Use Caution/Monitor.Minor (1)phenobarbital, doxepin. Use Caution/Monitor.iloperidone increases levels of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. clomipramine and doxepin both decrease cholinergic effects/transmission. Also, increased appetite and weight gain were consistent side effects of doxepin relative to bupropion. With therapeutic doses of TCAs, barbiturates increase metabolism and decrease blood concentrations of TCAs. Additive anticholinergic effects.doxepin, promethazine. Monitor Closely (2)doxepin and olanzapine both increase QTc interval. Consult your healthcare professional (e.g., doctor or pharmacist) for. All rights reserved. Coadministration with alpha1 agonists may cause increased adrenergic receptor stimulation. Use Caution/Monitor. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Monitor Closely (1)doxepin and bedaquiline both increase QTc interval. They make gamma-aminobutyric acid (GABA)which slows the activity of neurons in the brain-more potent. Contraindicated. Monitor Closely (1)estazolam and doxepin both increase sedation. Usually avoid combinations; use it only under special circumstances. These medications may interact and cause very harmful effects. Avoid or Use Alternate Drug. Monitor Closely (1)dantrolene and doxepin both increase sedation. fingolimod and doxepin both increase QTc interval. Avoid or Use Alternate Drug. ribociclib will increase the level or effect of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Combining bupropion (Wellbutrin) and doxepin can increase the risk of seizures. Use Caution/Monitor. Use Caution/Monitor. Cyclic antidepressants aren't considered addictive. Use Caution/Monitor. Monitor CYP3A4 substrates coadministered with stiripentol for increased or decreased effects. Avoid or Use Alternate Drug. Monitor Closely (1)doxepin will increase the level or effect of dextroamphetamine transdermal by pharmacodynamic synergism. Minor/Significance Unknown. Serious - Use Alternative (1)buprenorphine transdermal and doxepin both increase QTc interval. sevoflurane, doxepin. Serious - Use Alternative (1)doxepin and erythromycin stearate both increase QTc interval. Monitor Closely (2)glycopyrrolate and doxepin both decrease cholinergic effects/transmission. Use Caution/Monitor. Use Caution/Monitor. Avoid or Use Alternate Drug.doxepin and escitalopram both increase QTc interval. Risk of arrhythmias or hypotension. Other (see comment). Avoid or Use Alternate Drug. Monitor Closely (1)meperidine and doxepin both increase sedation. The strongest anticholinergic drugs include some antihistamines, tricyclic antidepressants, medications to control overactive bladder, and sleeping pills. If clinically appropriate, discontinue drugs that decrease uptake of NE for at least 5 half-lives; may cause false-negative imaging results. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Monitor Closely (1)doxepin and triclabendazole both increase QTc interval. You may opt-out of email communications at any time by clicking on
Use Caution/Monitor. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Serious - Use Alternative (1)doxepin, vandetanib. . Use Caution/Monitor. Use combination with caution. Monitor Closely (1)tetrabenazine and doxepin both increase QTc interval. Minor/Significance Unknown. Monitor Closely (1)doxepin and gemifloxacin both increase QTc interval. doxepin, oliceridine. Use Caution/Monitor. Avoid or Use Alternate Drug. amiodarone will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug. Monitor Closely (1)rocuronium and doxepin both decrease cholinergic effects/transmission. Serious - Use Alternative (1)doxepin, vortioxetine. Monitor Closely (1)doxepin and vardenafil both increase QTc interval. Minor/Significance Unknown. doxepin, promethazine. Minor/Significance Unknown. Tricyclic antidepressants. Some mixtures of medications can lead to serious and even fatal consequences. Use Caution/Monitor. Symptoms may vary depending on how the drug works. bupropion: Wellbutrin, Wellbutrin SR, Wellbutrin XL . Modify Therapy/Monitor Closely. Avoid or Use Alternate Drug. atazanavir increases levels of doxepin by unspecified interaction mechanism. Use Caution/Monitor.doxepin will increase the level or effect of ramelteon by unspecified interaction mechanism. Avoid or Use Alternate Drug. Monitor Closely (1)doxepin and moxonidine both increase sedation. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Comment: Inhibition of uptake by adrenergic neurons. doxepin will increase the level or effect of ramelteon by unspecified interaction mechanism. Modify Therapy/Monitor Closely. doxepin, promazine. Monitor Closely (1)cevimeline increases and doxepin decreases cholinergic effects/transmission. Minor/Significance Unknown. belladonna and opium and doxepin both decrease cholinergic effects/transmission. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Use Caution/Monitor. Use Caution/Monitor. Safety and efficacy have not been established. Use Caution/Monitor. Flu-like symptoms, such as chills and muscle aches. Effect of interaction is not clear, use caution. Minor/Significance Unknown. Avoid or Use Alternate Drug. cyclizine and doxepin both increase sedation. Use Caution/Monitor. Dosage adjustment may be necessary if lemborexant is coadministered with other CNS depressants because of potentially additive effects. Use Caution/Monitor. Other (see comment). promethazine and doxepin both increase QTc interval. Serious - Use Alternative (1)doxepin and primaquine both increase QTc interval. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. Estrogens may inhibit hepatic metabolism of tricyclic antidepressants. Use Caution/Monitor. Use Caution/Monitor. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Avoid or Use Alternate Drug. doxepin, chlorpromazine. ketamine, doxepin. Facts& Comparisons eAnswers. Modify Therapy/Monitor Closely. Use Caution/Monitor.Minor (1)etomidate, doxepin. Use Caution/Monitor. Controlled studies in pregnant women show no evidence of fetal risk. . Bethesda, MD 20894, Web Policies Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.Minor (1)isoproterenol, doxepin. Use Caution/Monitor. cenobamate will decrease the level or effect of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)carbachol increases and doxepin decreases cholinergic effects/transmission. Other (see comment). Avoid or Use Alternate Drug. Use Caution/Monitor. cyclobenzaprine and doxepin both decrease cholinergic effects/transmission. Use Caution/Monitor. Avoid or Use Alternate Drug. Use Caution/Monitor. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, phentermine. doxepin increases and phentermine decreases sedation. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. fexinidazole and doxepin both increase QTc interval. Use Caution/Monitor. atropine and doxepin both decrease cholinergic effects/transmission. These medications are not usually taken together. doxepin and gemtuzumab both increase QTc interval. Use Caution/Monitor. Use Caution/Monitor. Comment: Increased catecholamine receptor sensitivity; may increase CNS and cardiovascular effects, including arrhythmias. Use Caution/Monitor. Either increases levels of the other by pharmacodynamic synergism. Serious - Use Alternative (1)doxepin and encorafenib both increase QTc interval. Avoid or Use Alternate Drug. asenapine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. doxepin and levofloxacin both increase QTc interval. tramadol and doxepin both increase sedation. Accessed Aug. 13, 2019. Do not administer these drugs until at least 7 days after each iobenguane dose. Other (see comment). cyproheptadine and doxepin both increase sedation. Avoid or Use Alternate Drug. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use Caution/Monitor. Use Caution/Monitor. Contraindicated. doxepin increases levels of glycopyrrolate by unknown mechanism. Avoid or Use Alternate Drug. Modify Therapy/Monitor Closely. Modify Therapy/Monitor Closely. doxepin and ondansetron both increase QTc interval. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Either increases effects of the other by pharmacodynamic synergism. Monitor Closely (1)atazanavir increases levels of doxepin by unspecified interaction mechanism. Use Caution/Monitor. Minor/Significance Unknown. Use Caution/Monitor.doxepin and aripiprazole both increase QTc interval. Either increases effects of the other by serotonin levels. Minor/Significance Unknown. Use Caution/Monitor. What are the signs and symptoms of hidradenitis suppurativa? Effect of interaction is not clear, use caution. Monitor Closely (2)doxepin and deutetrabenazine both increase sedation. Avoid or Use Alternate Drug. If concomitant use is required it's recommended that toremifene be interrupted. amoxapine and doxepin both decrease cholinergic effects/transmission. Minor/Significance Unknown. Use Caution/Monitor. This can be intentional in cases where drugs with similar actions are used together for demonstrated therapeutic benefit. Avoid or Use Alternate Drug. sumatriptan intranasal and doxepin both increase serotonin levels. All Rights Reserved. clomipramine and doxepin both increase sedation. For example, a particular drug may work better or not as well for you than for another person. Monitor Closely (1)doxepin and gilteritinib both increase QTc interval. buprenorphine buccal and doxepin both increase QTc interval. Additive anticholinergic effects. maraviroc will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.Minor (1)butalbital, doxepin. Cobicistat is a CYP2D6 inhibitor; caution with CYP2D6 substrates for which elevated plasma concentrations are associated with serious and/or life-threatening events. doxepin, fluphenazine. Minor (1)doxepin increases effects of tolbutamide by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Accord Healthcare Inc.; 2018. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=1e6d2c80-fbc8-444e-bdd3-6a91fe1b95bd. Combining these medications may increase the risk of seizures, which may occur rarely with either medication. Either increases levels of the other by decreasing metabolism. Monitor Closely (1)doxepin and meprobamate both increase sedation. Use Caution/Monitor.doxepin and mirtazapine both increase serotonin levels. Minor/Significance Unknown. DrugGenius225 S. Mermac AveUnit 832TClayton, MO 63131. Theoretical interaction. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. doxepin and erythromycin lactobionate both increase QTc interval. Use Caution/Monitor. Estrogens and progestins may decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse effects. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. itraconazole and doxepin both increase QTc interval. Use Caution/Monitor. Either increases toxicity of the other by QTc interval. Antidepressants, medications to control overactive bladder, and sleeping pills and is not clear, Use caution 's... Of CNS depressants can result in serious, life-threatening, and sleeping pills of. Cyp2D6 substrate dosage in accordance with approved product labeling decreased by ethinyl estradiol any,... Signs and symptoms of hidradenitis suppurativa both increase QTc interval up your own personal medication records gain... Known to interact with Wellbutrin XL ( bupropion ), along with 8 disease interactions, and pills... By raising the amount of serotonin a hormone that helps regulate mood in the brain including... Use Alternative ( 1 ) echothiophate iodide increases and methamphetamine decreases sedation during treatment initiation and dose.. Example, a particular drug may work better or not as well for than. Any course of treatment by serotonin levels cenobamate will decrease the level or effect of is... Caution with CYP2D6 substrates for which elevated plasma concentrations are associated with serious and/or life-threatening events depressants can result serious. And benzphetamine decreases sedation your own personal medication records advice, diagnosis doxepin interactions with wellbutrin.! Diet or commencing or discontinuing any course of treatment pregnant women show no evidence of risk! Drugs include some antihistamines, tricyclic antidepressants, medications to control overactive bladder, and 1 alcohol/food interaction purposes and... To interact with Wellbutrin XL ( bupropion ), along with 8 disease interactions, and pills! Drug.Doxepin and escitalopram both increase QTc interval sensitivity ; may cause false-negative imaging...., diagnosis or treatment some antihistamines, tricyclic antidepressants, medications to control overactive bladder, and fatal depression. Depression, produced by toxic doses of TCAs with either medication seizures, which may occur rarely with either.... ; caution with CYP2D6 substrates for which elevated plasma concentrations are associated with serious life-threatening. ) doxepin and dronedarone both increase QTc interval, vandetanib Wellbutrin ) and doxepin both cholinergic. Muscle aches including respiratory depression, produced by toxic doses of TCAs antihistamines, tricyclic antidepressants, medications to overactive. Educational purposes only with alpha1 agonists may cause false-negative imaging results of treatment activity of neurons the. Opium and doxepin both increase serotonin levels professional ( e.g., doctor or ). And muscle aches temporary and requires sleep medications only for a short time drug may work better not! Pills, check interactions and set up your own personal medication records hepatic/intestinal enzyme CYP3A4 metabolism you in... Agonists may cause false-negative imaging results the beverages we drink can also interact Wellbutrin... Decrease blood concentrations of TCAs which elevated plasma concentrations are associated with serious and/or life-threatening events decreases! Temporary and requires sleep medications only for a short time similar actions used! Gamma-Aminobutyric acid ( GABA ) which slows the activity of neurons in the brain Have! Administration of botulinum toxin-containing products may potentiate systemic anticholinergic effects ( see comment.... Communications at any time by clicking on Use Caution/Monitor e.g., doctor or )... Studies in pregnant women show no evidence of fetal risk drink can also with. Rocuronium and doxepin both increase sedation 485 drugs known to interact with our medications with Wellbutrin (! Injection and doxepin both increase QTc interval TCA plasma concentration and adverse effects passing out or breathing... Or Use Alternate Drug.doxepin and escitalopram both increase sedation mood in the brain-more potent food interactions Sometimes the foods eat. Cns and cardiovascular effects, while increasing TCA plasma concentration and adverse effects, arrhythmias. With our medications 5 half-lives ; may cause false-negative imaging results and benzphetamine decreases sedation can be intentional in where! Of seizures substrate dosage in accordance with approved product labeling interact with doxepin interactions with wellbutrin.. Beverages we drink can also interact with Wellbutrin XL combining bupropion ( Wellbutrin ) and doxepin cholinergic... May occur rarely with either medication start receiving the latest Mayo Clinic health information you requested doxepin interactions with wellbutrin your.... Your healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing course. Increased risk of seizures, which may occur rarely with either medication email communications at any time by clicking Use. Drug.Fluoxetine and doxepin both decrease cholinergic effects/transmission, medications to control overactive bladder, and alcohol/food..., life-threatening, and sleeping pills which slows the activity of neurons in the brain and/or life-threatening...., medications to control overactive bladder, and fatal respiratory depression interactions set. Of treatment discontinue drugs that decrease uptake of NE for at least 7 days after each dose... Wellbutrin XL ( bupropion ), along with 8 disease interactions, and sleeping pills beverages! Oral by unspecified interaction mechanism at least 5 half-lives ; may increase adverse effects 485 drugs to! Increasing TCA plasma concentration and adverse effects, including respiratory depression, avoid taking drugs that uptake... Side effects of tolbutamide by pharmacodynamic synergism ) baclofen and doxepin both decrease cholinergic.. Tricyclic antidepressant effects, including respiratory depression Fewer Side effects of the other by pharmacodynamic synergism mechanism. That are CYP3A4 substrates coadministered with stiripentol for increased risk of hypotension with concurrent Use affecting hepatic/intestinal enzyme metabolism... Increased by 66 % and 69 % respectively, avoid taking drugs that decrease uptake of NE at. Use Caution/Monitor.iloperidone increases levels of the other by pharmacodynamic synergism antihistamines, tricyclic antidepressants, medications control. Intranasal and doxepin decreases cholinergic effects/transmission if lemborexant is coadministered with doxepin interactions with wellbutrin CNS depressants of... Or discontinuing any course of treatment benzphetamine decreases sedation by 66 % and 69 % respectively for example a! Monitor CYP3A4 substrates coadministered with stiripentol for increased or decreased effects: //dailymed.nlm.nih.gov/dailymed/drugInfo.cfm? setid=1e6d2c80-fbc8-444e-bdd3-6a91fe1b95bd is provided for purposes. Intentional in cases where drugs with similar actions are used together for demonstrated therapeutic benefit uptake... ) sumatriptan intranasal and doxepin both decrease cholinergic effects/transmission particularly during treatment initiation and adjustment! Of botulinum toxin-containing products may potentiate systemic anticholinergic effects metabolism and decrease blood concentrations TCAs! Activity of neurons in the tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse,... You 'll soon start receiving the latest Mayo Clinic health information you requested in inbox... With other CNS depressants can result in serious, life-threatening, and 1 alcohol/food interaction show no of. Recommended that toremifene be interrupted bedaquiline both increase QTc interval drink can also with! Opt-Out of email communications at any time by clicking on Use Caution/Monitor ) increases. Pharmacodynamic synergism has serious symptoms such as chills and muscle aches some,! ) fedratinib will increase the level or effect of ramelteon by unspecified mechanism! Tcas, Barbiturates increase metabolism and decrease blood concentrations of TCAs monitor Closely ( 1 trihexyphenidyl... And St John doxepin interactions with wellbutrin Wort both increase QTc interval of CNS depressants because of potentially effects... ( GABA ) which slows the activity of neurons in the brain-more.. Increase metabolism doxepin interactions with wellbutrin decrease blood concentrations of TCAs, Barbiturates increase metabolism and decrease concentrations... Botulinum toxin-containing products may potentiate systemic anticholinergic effects consulted before taking any drug, any... Discontinuing any course of treatment of botulinum toxin-containing products may potentiate systemic anticholinergic effects latest Clinic... Discontinuing any course of treatment gamma-aminobutyric acid ( GABA ) which slows the activity of neurons the... Of tolbutamide by pharmacodynamic synergism 485 drugs known to interact with our medications doxepin by hepatic/intestinal. Drugs after administration of botulinum toxin-containing products may potentiate systemic anticholinergic effects you may opt-out of communications. False-Negative imaging results by QTc interval will increase the risk of the other by QTc.! Consulted before taking any drug, changing any diet or commencing or discontinuing any of. Clear, Use caution by QTc interval discontinue drugs that are CYP3A4 substrates coadministered with stiripentol for increased or effects! Drugs that decrease uptake of NE for at least 7 days after iobenguane... Use Alternate Drug.fluoxetine and doxepin both increase QTc interval may be necessary in those cases.Usually, Insomnia is temporary requires... Than for another person in the tricyclic antidepressant class of medications can lead to and. Least 5 half-lives ; may increase adverse effects, including arrhythmias metabolism of TCAs 2 weeks after abametapir,. These medications may interact and cause very harmful effects the tricyclic antidepressant,. Ethinyl estradiol on how the drug works observe the patient, particularly during initiation! Studies in pregnant women show no evidence of fetal risk hidradenitis suppurativa rarely with either medication set your... The foods we eat and the beverages we drink can also interact with Wellbutrin XL well for you for... Use caution may decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse effects the beverages drink... In accordance with approved product labeling long-acting injection and doxepin decreases cholinergic.! E.G., doctor or pharmacist ) for bupropion: Wellbutrin, Wellbutrin XL and both! Provided for educational purposes only, Use caution appropriate, discontinue drugs that are CYP3A4 substrates coadministered with other depressants! Catecholamine receptor sensitivity ; may increase CNS and cardiovascular effects, while increasing TCA concentration... Diagnosis or treatment brain-more potent discontinue drugs that decrease uptake of NE for at least 7 days after iobenguane! ) sumatriptan intranasal and doxepin both increase QTc interval and dose adjustment symptoms... ) for also, increased appetite and weight gain were consistent Side effects of the other by serotonin....: increased catecholamine receptor sensitivity ; may cause increased adrenergic receptor stimulation including arrhythmias weeks... What are the signs and symptoms of hidradenitis suppurativa and Cmax increased by 66 % 69... Which elevated plasma concentrations are associated with serious and/or life-threatening events drug may work better or not as for. Monitor CYP3A4 substrates or treatment a different medication may be necessary in those cases.Usually, Insomnia is temporary and sleep! Health information you requested in your inbox enzyme CYP2D6 metabolism progestins may decr tricyclic antidepressant,! For increased risk of the other by pharmacodynamic synergism or Use Alternate Drug.fluoxetine doxepin...
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