Ellagic acid facilitates indomethacin-induced gastric ... Antiviral activity and possible mode of action of ellagic ... Ellagic acid Foods | Free Full-Text | The New Face of Berries: A Review ... However, only a few modes of action have been proposed for ellagic acid's influence on cancer cells. However, further investigations are needed to understand their specific role on fungal cell walls. (A) Several dietary products (e.g., pomegranate) are rich in ellagitannins (ETs), a class of natural (poly)phenols. Type Small Molecule Groups Investigational Structure. Ellagic acid by several inhibitory mechanisms assists cancer cells to undergo the epithelial mesenchymal transition, chemotaxis, and cell migration. Therefore, further kinetic studies are needed to understand its antioxidative capacity completely. Ellagic acid appears to inhibit chemical-induced esophageal carcinogenesis in animals .It down-regulates insulin-like growth factor IGF-II and activates p53/p21 expression, leading to cell cycle arrest at the G1/S phase and apoptosis .In vitro studies report that ellagic acid protects cells from oxidative DNA damage caused by hydrogen peroxide and bleomycin . … Fruit, vegetables, and mushrooms for the preparation of ... It affects ∼10% of the world population [1]. These characteristics may limit its usefulness as a medicine. (HRV-2, HRV-3, and HRV-4) of the tannin ellagic acid from L. speciosa leaves, compared to commercial pure ellagic acid and ribavirin, a currently used broad-spectrum antiviral agent [21]. Ellagic acid's therapeutic action mostly involves antioxidant and anti-proliferative/anti-cancer effects. The exact mechanism of action of ellagic acid in its different potential indications is still being investigated. After oral consumption, ellagic acid reaches maximum concentrations in about 1 hour. Ellagic acid is a natural phenolic compound which has been described as an inhibitor of the melanogenesis process , , , , , , , .This compound inhibits the first steps of the melanin biosynthesis pathway which are catalyzed by tyrosinase and is used as an ingredient in whitening creams and other cosmetics , .In order to check the action of ellagic acid as an … The dietary anticancer agent ellagic acid is a potent inhibitor of DNA topoisomerases in vitro. Ellagic Acid, Kaempferol, and Quercetin from Acacia nilotica: Promising Combined Drug With Multiple Mechanisms of Action Curr Pharmacol Rep . Author information: (1)Zoology Department, Faculty of Women for Arts, Science and Education, Ain Shams University, Cairo, Egypt. Antitumor effect and mechanism of an ellagic acid ... Ellagic acid: Uses, Interactions, Mechanism of Action ... However, not many papers dealing with the electrochemical properties and protolytic equilibria of ellagic acid have been pub-lished so far. Pre-clinical studies indicate anticarcinogenic effects of ellagic acid against liver, esophageal, prostate, and colorectal cancer cell lines (3) (4) (5) (6) . It was also shown to induce apoptosis and potentiate all-trans retinoic acid myeloid differentiation therapy in human leukemia HL-60 cells (9). Download . Ellagic acid appears to inhibit chemical-induced esophageal carcinogenesis in animals . [[2,4-5] Several mechanisms by which phytochemicals, such as ellagic acid, can alter carcinogenesis have been identified. The neuroprotective effects of ellagic acid to protect the neurons against neurodegenerative events are due to its antioxidant effect, iron chelating, and mitochondrial protective effect. Ellagic acid (EA) is a naturally polyphenolic phytonutrient found in wide varieties of fruits, berries and nuts. Ellagic acid chelates divalent cations such as Zn 2+, Ca 2+, Fe 2+, Cd 2+, Cu 2+, which enhance the ability of ellagic acid to inactivate metalloproteinases and impart antiangiogenic activity (Losso et al., 2004). Njomnang Soh P, Witkowski B, Gales A, et al. Beserra AM, Calegari PI, Souza Mdo C, et al. Ellagic acid (EA) is a polyphenol found in several fruits and plants. Recent in vitro and in vivo experiments have revealed that EA elicits anticarcinogenic effects by inhibiting tumor cell proliferation, inducing apoptosis, breaking DNA binding to carcinogens, blocking virus infection, and disturbing inflammation, angiogenesis, and drug-resistance processes required for tumor … Abstract Ellagic acid is a biologically active polyphenol found in numerous fruits and vegetables. These characteristics may limit its usefulness as a medicine. PMID: 23029306. Ellagic acid, a polyphenolic compound present in fruit and berries, has recently been the object of extensive research for its antioxidant activity, which might be useful for the prevention and treatment of cancer, cardiovascular pathologies, and neurodegenerative disorders. 1-(3,4-dimethoxyphenyl)- 3-dodecanone and ellagic acid constitute attractive pharmacological tools to investigate the functional consequences of enhancing SR Ca’+, uptake by … In the present study, JNE2, an ellagic acid derivative that was isolated from a traditional Chinese herb, Euphorbia hylonoma Hand.-Mazz. integral component of the cellular mechanism of action responsible for its therapeutic effects, toxicities, or both (Priestman, 2008). Ellagic acid may bind to chemicals that cause cancer, and it may also prevent the growth of cancer cells. Ellagic acid is a common metabolite present in many medicinal plants and vegetables. The interaction of Quercetin with Coronavirus replicase polyprotein 1 ab will inhibit the transcription and replication of viral RNAs [26]. Ellagic acid has a chemoprotective effect in cellular models by reducing oxidative stress [328]. Ellagic acid is an organic heterotetracyclic compound resulting from the formal dimerisation of gallic acid by oxidative aromatic coupling with intramolecular lactonisation of both carboxylic acid groups of the resulting biaryl. The main goal of this review is to critically analyze the molecular mode of action of ellagic acid against neurodegeneration. MOL SDF 3D-SDF PDB SMILES InChI. Anti-inflammatory effect and mechanism of action of ellagic acid-3,3',4-trimethoxy-4'- O-α-L-rhamnopyranoside isolated from Hopea parviflora in lipopolysaccharide-stimulated RAW 264.7 macrophages Nat Prod Res. The main goal of this review is to critically analyze the molecular mechanism of action of … Results from recent research have increased the interest in ellagic acid, both as a potential protective agent of the liver and skin and as a possible anticancer agent, due to the specific mechanisms affecting cell proliferation, apoptosis, DNA damage, and angiogenesis. The influential property of ellagic acid to protect the neurons in neurodegenerative disorders is due to its antioxidant effect, iron chelating and mitochondrial protective effect. 17.2.7 Ellagic Acid. Ellagic acid (Figure 17.1), a polyphenol found in fruits and vegetables including blackberries, raspberries, strawberries, cranberries, walnuts, pecans, pomegranates, wolfberry and other plant foods, is one of the well-studied phytochemicals. It possesses antioxidant, anti-mutagenic and anticancer properties. Nutr Cancer 1995;23:121-30.. View abstract. The authors attributed the enzyme inhibition activities of both enzymes to the phenolic compounds (i.e., rutin, catechin, gallic acid, syringic acid, and ellagic acid) found in the extracts. The best sources of ellagic acid in the diet are strawberries, raspberries, blackberries, cherries, and walnuts. A raspberry (Rubus idaeus L.) fruit extract contains various antioxidant active compounds, particularly ellagic acid (EA); however the exact intracellular mechanism of their action is not fully understood. It can also act on drug metabolizing enzymes and prevent the formation of toxic metabolites ( Hayeshi et al., 2007 ). 2018 Feb 26;19(2):387-393. doi: 10.22034/APJCP.2018.19.2.387. However, ellagic acid is poorly absorbed and is also eliminated quickly from the body. It inhibited growth of Caco-2 cell line, possibly mediated by regulation of matrix metalloproteinases, vascular endothelial growth factor expression, and induction of apoptosis [ 258 ]. DrugBank Induction of glutathione S-transferase (GST) enzymes can increase detoxification of carcinogens and reduce carcinogen-induced mutagenesis and tumorigenesis. The antitumour activity of ellagic acid has proven an effective inhibitor of chemically induced cancer in the pulmonary and hepatic systems, as well as in the epidermis of mice. Acacetin, Ellagic acid, Kaempferol, and Quercetin with HIV integrase enzyme will inhibit the viral DNA integration into hostDNAleadingtothesuppressionofreplicationcycle[52]. It inhibits the adverse effect of UVB radiation (Ultraviolet B), protects skin against degradation and exhibits anti-inflammatory action [43] [44][45]. Ellagic acid is an antioxidant antiproliferative agent found in wide range of fruits and vegetables. Although one can find numerous studies devoted to the investigation of antioxidative activity of ellagic acid (EA) in the scientific literature, the mechanisms of its action have not yet been fully clarified. The exact mechanism of action of ellagic acid in its different potential indications is still being investigated. Nutr Cancer 1995;23:121-30.. View abstract. We previously demonstrated the suppressive effect of an antioxidant (NAC) on in vitro EA antiplasmodial activity [3] and supposed that the antiplasmodial action of EA was due to increased ROS generation, deleterious to P. falciparum . Dell'Agli M, Parapini S, Basilico N, et al. The possible mechanisms of action of ellagic acid on P. falciparum are discussed in light of the results. Ellagic Acid Holds Promise Against Hepatocellular Carcinoma in an Experimental Model: Mechanisms of Action Zaazaa AM(1), Lokman MS, Shalby AB, Ahmed HH, El-Toumy SA. Potential mechanisms include It aids in the maintenance of cell adhesion molecule Click here to view Ellagic acid is a naturally occurring substance. The mechanism of indomethacin-induced gastric ulcer healing by ellagic acid (EA) in experimental mice model is described in our study. Figure 3: Effects of ellagic acid on tumor metastasis. Ellagic acid (EA) is a well-known polyphenolic compound, which has been found in both free and complex modes in several medicinal plants such as pomegranate, walnut, and berries. … Cell culture studies indicate that pure ellagic acid works through a p53-independent mechanism. The modulatory action on immune system and the inhibitory effect on HBeAg secretion impart anti-HBV activity to ellagic acid. In order to seeking for its mode of action, ellagic acid evoked a significant enhancement in GSH while suppressing NADPH and … Ellagic acid retracted the tumor incidence basically by acting at the initiation phase of the carcinogenesis. PLoS One. Ellagic acid (EA) is a natural phenolic constituent. Ellagic acid may bind to chemicals that cause cancer, and it may also prevent the growth of cancer cells. 2019 Nov 12;1-5. doi: 10.1080/14786419.2019.1690486. Ellagic acid may also interfere with intracellular signaling pathways, such as those that regulate proliferation, induce apoptosis and respond to oxidative stress ( 36 – 39 ). Promising combined drug with multiple mechanisms of action. Gastroprotective and ulcer-healing contributed substantially to the non-toxic effect of HEHs observed mechanisms of ellagic acid in experimental rats. Ellagic acid is a dilactone of hexahydroxydiphenic acid that occurs naturally in berries and nuts such as the raspberry, strawberry, walnut, and pecan. Gastric ulcer is a common ailment throughout the world, in which the gastric mucosa becomes damaged and perforations lead to bleeding. 3D. EA has Human rhinoviruses (HRVs) are responsible for more than half of all cases of the common cold and cause billions of USD annually in medical visits and school and work absenteeism. A berry compound known as ellagic acid has been tested in a phase 1 clinical trial . Although many articles have reported anticancer properties for this compound, its mechanism of action has not been fully elucidated. between ellagic acid and monoclonal antibodies raised against phospholamban. The objective of this study was to investigate ellagic acid-induced cell cycle arrest and apoptosis in T24 human bladder cancer cells in vitro. To further understand the antimalarial mechanism of action of EA in vitro, we evaluated the effects of EA, ascorbic acid and N-acetyl-L-cysteine (NAC), alone and/or in combination on the production of reactive oxygen species (ROS) during the trophozoite and schizonte stages of the erythrocytic cycle of P. falciparum. Gastroprotective and ulcer-healing mechanisms of ellagic acid in experimental rats. Scope. It is found in many fruits and vegetables, including raspberries, strawberries, cranberries, and pomegranates. Ellagic Acid, Kaempferol, and Quercetin from Acacia nilotica: Promising Combined Drug With Multiple Mechanisms of Action Curr Pharmacol Rep . Ellagic acid (EA) is a polyphenol known for its antiplasmodial properties –. Dell'Agli M, Parapini S, Basilico N, et al. The antiarthritic, analgesic, antioxidant, antihelminthic activities of the leaf extracts have been investigated (Shruthi et al., 2012a &, 2012b). The neuroprotective effects of ellagic acid to protect the neurons against neurodegenerative events are due to its antioxidant effect, iron chelating, and mitochondrial protective effect. have an antioxidant or radical scavenging mechanism as part of their activity (Kirtikar and Basu, 1980). While the mode of action of caffeic acid derivatives has been previously described, our study is the first to gain insight into the mechanism of action of caffeic acid phenethyl ester and ellagic acid on both C. auris and C. albicans. The electro-oxidation mechanism of ellagic acid was studied in methanol aqueous media (1:1, v/v) Ellagic acid (EA) is a polyphenol found at high The invention discloses the purposes that Ellagic Acid Derivatives and its pharmaceutically acceptable salt are used to treat hyperuricemia, ellagic acid class compound of the present invention not only shows stronger In-vitro Inhibitory Effect to xanthine oxidase, the serum uric acid level with hyperuricemia mouse is also can obviously reduce, the treatment of gout or gout … Author information: (1)Zoology Department, Faculty of Women for Arts, Science and Education, Ain Shams University, Cairo, Egypt. Upon ingestion, ETs are hydrolyzed in the small intestine into ellagic acid (EA), reaching the colon. Considering the use of this species in ethnomedicine, its anti-inflammatory and antioxidant activities, our study investigated the antiulcerogenic activity of the Spondias mombin ethanolic extract (SmEE), isolated gallic acid (GA), and ellagic acid (EA) and in association between gallic acid and ellagic acid. Uses & Effectiveness. Metabolism of ellagitannins to yield bioactive urolithins with potential action for diabetes. The hydroxyl moiety at the C8 position of ellagic acid (-OH; dotted circle) is lost in isourolithin A via isomerization and, in urolithin B, via a cleavage reaction during metabolic conversion in the gut. 2019 Nov 12;1-5. doi: 10.1080/14786419.2019.1690486. Similar Structures. Journal of Agricultural and in the present study, as ellagic acid is 6% of the dry extract. It down-regulates insulin-like growth factor IGF-II (6) and activates p53/p21 expression, leading to cell cycle arrest at the G1/S phase and apoptosis (12) . However, ellagic acid is poorly absorbed and is also eliminated quickly from the body. Although one can find numerous studies devoted to the investigation of antioxidative activity of ellagic acid (EA) in the scientific literature, the mechanisms of its action have not yet been fully clarified. Implication of glutathione in the in vitro antiplasmodial mechanism of action of ellagic acid. Ellagic acid's therapeutic action mostly involves antioxidant and anti-proliferative effects. 1. The aim of this study is to research the effects of the polyphenol ellagic acid (EA) on brain cells and to explore its mechanism of action, and to evaluate whether EA can be safely utilized by humans as a functional food or therapeutic agent. Its protective role justifies numerous attempts to include it in functional food preparations and in dietary … The main goal of this review is to critically analyze the molecular mechanism of action of … Anti-inflammatory effect and mechanism of action of ellagic acid-3,3',4-trimethoxy-4'- O-α-L-rhamnopyranoside isolated from Hopea parviflora in lipopolysaccharide-stimulated RAW 264.7 macrophages Nat Prod Res. An assessment was made of the cytotoxic and antiviral activities and possible mode of action of the tannin ellagic acid from the leaves of Lagerstroemia speciosa toward HeLa cells and three rhinoviruses, HRV-2, -3, and -4. Ulcer index (UI) and myeloperoxidase (MPO) activity of the stomach tissues showed maximum ulceration on the third day after indomethacin (18 mg/kg, single dose) administration. To investigate the mechanism of action of two antiplasmodial compounds, ellagic acid and 3,4,5-trimethoxyphenyl (6'-O-galloyl)-beta-D-glucopyranoside (TMPGG), we studied in vitro two metabolic reactions of intraerythrocytic parasites: the activity of recombinant plasmepsin II, one of the haemoglobin proteases, and the detoxification of haematin into beta-haematin. Latest research finds mechanism of action of ellagic acid. Ellagic Acid Holds Promise Against Hepatocellular Carcinoma in an Experimental Model: Mechanisms of Action Zaazaa AM(1), Lokman MS, Shalby AB, Ahmed HH, El-Toumy SA. The dietary anticancer agent ellagic acid is a potent inhibitor of DNA topoisomerases in vitro. Ellagic Acid Holds Promise Against Hepatocellular Carcinoma in an Experimental Model: Mechanisms of Action Asian Pac J Cancer Prev . Ellagic acid has the capacity to regulate intimate intracellular mechanisms by direct interaction with double-stranded DNA (Girish et al., 2009c; Thulstrup et al., 1999). Mechanism of action. and ellagic acid (5) (-3.076) has the highest solubility. Ellagic acid is one of these phenolic compounds, but the exact mechanism of its action is still unclear. The antiviral property and mechanisms of action of the constituent were elucidated using sulforhodamine B (SRB) assay and real-time re- The modulatory action on immune system and the inhibitory effect on HBeAg secretion impart anti-HBV activity to ellagic acid. 2012;7(9):e45906. The study referenced at the beginning of this news story was designed to investigate the inhibitory effects of ellagic acid on the growth of hormone receptor positive MCF-7 breast cancer cells. ... Understanding the biological differences in flavonoids and cellular action mechanisms. It is these properties that have spurred preliminary research into the potential health benefits of ellagic acid consumption [326, 327]. EA has A series of metabolites called urolithins are formed from ellagic acid via the enzymatic action of gut microbes. Ellagic Acid, Kaempferol, and Quercetin from Acacia nilotica: Promising Combined Drug With Multiple Mechanisms of Action Mosab Yahya Al-Nour1 & Musab Mohamed Ibrahim1 & Tilal Elsaman1 Published online: 14 May 2019 # Springer Nature Switzerland AG 2019 Abstract Varieties of both endogenous and exogenous factors, including acid, pepsin, stress, and noxious agents such as alcohol, non-steroidal anti-inflammatory drugs (NSAIDs), Helicobacter pylori bacteria, smokin… The parasitized erythrocytes were … For this purpose, tablets were produced containing 16 mg of ellagic acid with 100 mg of pulp from the fruit of an evergreen tree called Cherimoya, soursop, custard apple, and other common names (Annona muricata). 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